Our PEA Soothe Support Topical Cream provides an easy-to-use direct source of PEA (palmitoylethanolamide), a bio-identical acid amide synthesized by healthy tissue in response to inflammation.

As a non-psychoactive indirect endocannabinoid, PEA does not block pain signals like opioids or other analgesics. It works upstream by supporting glial and mast cells' healthy function, as supported by numerous studies. Glial cells are crucial to the nervous system and can exert inflammatory responses on neurons. Mast cells are immune system cells that respond to chemical signals from tissue injury. When mast cells degranulate, they release inflammatory cytokines, histamines, and other molecules, activating nociceptors (pain receptors).